Comparison
While SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137, TB-500 is studied for enhancing musculoskeletal and cardiac repair, wound healing, and promoting cell migration and differentiation via actin cytoskeleton remodeling21255.
While SS-31 works as a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143, TB-500 is a synthetic peptide comprising the LKKTETQ actin-binding motif of thymosin beta-4 that binds G-actin, sequesters actin monomers, and promotes cell migration, angiogenesis, and tissue repair1255.
SS-31 is 4 amino acids long, whereas TB-500 is longer as it has a length of 7 amino acids. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine. TB-500 is made up of a sequence of Lysine, Lysine, Lysine, Threonine, Glutamic acid, Threonine, Glutamine.
SS-31
TB-500
Binds monomeric actin (G-actin) rather than a classical cell-surface receptor, modulating actin polymerization at barbed and pointed ends55
SS-31
Not assigned in the current dataset.
TB-500
TMSB4X