Mechanism
Synthetic 15-amino-acid fragment of a gastric cytoprotective protein that promotes angiogenesis and tissue protection primarily by modulating VEGFR2 signaling, Src/caveolin-1–dependent eNOS activation, and nitric oxide production.111
Peptide record
BPC-157
Function
Investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects.111
Receptor
VEGFR2 (vascular endothelial growth factor receptor 2) on endothelial cells, with downstream eNOS and nitric-oxide–mediated signaling.11
Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val111
Length
15 amino acids
Organism or Origin
Synthetic peptide derived from a naturally occurring human gastric 'Body Protection Compound' isolated from human gastric juice.111
Gene
Not assigned in the current dataset.
Sources
- 1BPC-157 Research — Mechanism of Action, Preclinical Studies ..., https://peptide.co/research/bpc-157/
- 11BPC-157 - Wikipedia, https://en.wikipedia.org/wiki/BPC-157