Peptide record

AOD-9604

Mechanism

Synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis.61 71 111

Function

Studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials.71 111 115

Receptor

Acts indirectly on adipocytes, with mechanistic work implicating β3-adrenergic receptor–linked signaling in fat metabolism rather than direct GH receptor activation.71 111

Sequence

Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (YLRIVQCRSVEGSCGF)61 111

Length

16 amino acids

Organism or Origin

Synthetic peptide fragment derived from human pituitary growth hormone (GH1 protein). 111 107 114

Gene

GH1

Sources

61AOD-9604 – hGH 176–191 Analog Research Peptide ..., https://www.polybiotech.co/products/aod-9604-5mg
71Body-Fat Metabolism: AOD-9604 & GH Fragment 176–191 - Tide Labs, https://tidelabs.co.uk/blogs/articles/aod-9604-gh-frag-176-191-research-on-body-fat-metabolism
107Growth hormone 1 - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_1
111Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid ..., https://academic.oup.com/endo/article/142/12/5182/2988749
114GH1 growth hormone 1 GH GH-N GHN IGHD1B hGH-N, https://www.sigmaaldrich.com/US/en/genes/gh1
115Peptide Spotlight: AOD 9604 - The Wellness Lounge, https://www.akwellnesslounge.com/blog/peptide-spotlight-aod-9604

No related articles are linked to this peptide yet.