Peptable

Peptide record

AOD-9604

Function

AOD-9604 is a Metabolic peptide.

This Peptide is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115

Mechanism

AOD-9604 is a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111

AOD-9604 is a Hormone analog.

Receptor

Acts indirectly on adipocytes, with mechanistic work implicating β3-adrenergic receptor–linked signaling in fat metabolism rather than direct GH receptor activation71111

Length

16 amino acids

Organism or Origin

Synthetic peptide fragment derived from human pituitary growth hormone (GH1 protein) 111107114

Gene

GH1

Sequence

YLRIVQCRSVEGSCGF 61111

Tyrosine, Leucine, Arginine, Isoleucine, Valine, Glutamine, Cysteine, Arginine, Serine, Valine, Glutamic acid, Glycine, Serine, Cysteine, Glycine, Phenylalanine

16 residuesapprox. 1799.11 Dacharge +2 / -1 / net +1polar 6 • hydrophobic 5 • basic 2 • acidic 1 • special 2

Sequence-derived properties

Length

16 residues

Molecular weight

1817.12 Da

Average hydrophobicity

0.3

Unique amino acids

11

Residue class composition

polar

6 (37.5%)

hydrophobic

5 (31.3%)

basic

2 (12.5%)

special

2 (12.5%)

acidic

1 (6.3%)

Charge-category composition

neutral

13 (81.3%)

positive

2 (12.5%)

negative

1 (6.3%)

Amino acid composition

Arginine (Arg/R)

2 (12.5%)

Cysteine (Cys/C)

2 (12.5%)

Glycine (Gly/G)

2 (12.5%)

Serine (Ser/S)

2 (12.5%)

Valine (Val/V)

2 (12.5%)

Glutamic acid (Glu/E)

1 (6.3%)

Glutamine (Gln/Q)

1 (6.3%)

Isoleucine (Ile/I)

1 (6.3%)

Leucine (Leu/L)

1 (6.3%)

Phenylalanine (Phe/F)

1 (6.3%)

Tyrosine (Tyr/Y)

1 (6.3%)

Sources

  1. 61AOD-9604 – hGH 176–191 Analog Research Peptide ..., https://www.polybiotech.co/products/aod-9604-5mg
  2. 71Body-Fat Metabolism: AOD-9604 & GH Fragment 176–191 - Tide Labs, https://tidelabs.co.uk/blogs/articles/aod-9604-gh-frag-176-191-research-on-body-fat-metabolism
  3. 107Growth hormone 1 - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_1
  4. 111Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid ..., https://academic.oup.com/endo/article/142/12/5182/2988749
  5. 114GH1 growth hormone 1 GH GH-N GHN IGHD1B hGH-N, https://www.sigmaaldrich.com/US/en/genes/gh1
  6. 115Peptide Spotlight: AOD 9604 - The Wellness Lounge, https://www.akwellnesslounge.com/blog/peptide-spotlight-aod-9604

Related articles

No related articles are linked to this peptide yet.