Peptide record

SS-31

Mechanism

Mitochondria-targeted tetrapeptide d-Arg-dimethylTyr-Lys-Phe-NH2 that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production.46 37 137 143

Function

Improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders.46 37 137

Receptor

Cardiolipin-rich inner mitochondrial membrane; interacts with cardiolipin and associated mitochondrial proteins rather than a classical cell-surface receptor.46 137 143

Sequence

D-Arg-dimethylTyr-Lys-Phe-NH2 (d-Arg-Dmt-Lys-Phe-NH2)46 56

Length

4 amino acids

Organism or Origin

Fully synthetic Szeto–Schiller tetrapeptide; not encoded in the genome.46 37

Gene

Not assigned in the current dataset.

Sources

37The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action - PubMed, https://pubmed.ncbi.nlm.nih.gov/32273339/
46Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2 ... - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC11409442/
56Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2 ..., https://pubs.rsc.org/en/content/articlelanding/2024/ra/d4ra05517a
137Mitochondrial protein interaction landscape of SS-31 | PNAS, https://www.pnas.org/doi/10.1073/pnas.2002250117
143SS-31 Peptide: Mitochondrial Repair for Energy and Longevity, https://revolutionhealth.org/blogs/news/peptide-therapy-ss-31

No related articles are linked to this peptide yet.