Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

SS-31

Function

SS-31 is a Mitochondrial peptide.

This Peptide improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137

Mechanism

SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143

SS-31 is a Signaling modulator.

Receptor

Cardiolipin-rich inner mitochondrial membrane; interacts with cardiolipin and associated mitochondrial proteins rather than a classical cell-surface receptor46137143

Length

4 amino acids

Organism or Origin

Fully synthetic Szeto–Schiller tetrapeptide; not encoded in the genome4637

Gene

Not assigned in the current dataset.

Sequence

N-terminus
D-Arg
dimethylTyr
Lys
Phe
C-terminusNH2

D-R-dimethylTyr-K-F-NH2 4656

Arginine, dimethylTyr, Lysine, Phenylalanine

4 residuesapprox. 431.54 Dacharge +2 / -0 / net +2basic 2 • hydrophobic 11 residues without standard metadata

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sequence-derived properties are omitted because one or more residues are not present in the standard amino-acid dataset.

Sources

  1. 37The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action - PubMed, https://pubmed.ncbi.nlm.nih.gov/32273339/
  2. 46Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2 ... - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC11409442/
  3. 56Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2 ..., https://pubs.rsc.org/en/content/articlelanding/2024/ra/d4ra05517a
  4. 137Mitochondrial protein interaction landscape of SS-31 | PNAS, https://www.pnas.org/doi/10.1073/pnas.2002250117
  5. 143SS-31 Peptide: Mitochondrial Repair for Energy and Longevity, https://revolutionhealth.org/blogs/news/peptide-therapy-ss-31

Related articles

No related articles are linked to this peptide yet.

About this page

Published by
Peptable, as a structured reference dataset.
Dataset updated
Sourcing
Compiled from published literature and reference databases. See the editorial policy.

This page is reference information, not medical advice, and describes no dosages or administration protocols. Read the full disclaimer.