Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

TB-500

Function

TB-500 is a Signal peptide.

This Peptide is studied for enhancing musculoskeletal and cardiac repair, wound healing, and promoting cell migration and differentiation via actin cytoskeleton remodeling21255

Mechanism

TB-500 is a synthetic peptide comprising the LKKTETQ actin-binding motif of thymosin beta-4 that binds G-actin, sequesters actin monomers, and promotes cell migration, angiogenesis, and tissue repair1255

TB-500 is a Signaling modulator.

Receptor

Binds monomeric actin (G-actin) rather than a classical cell-surface receptor, modulating actin polymerization at barbed and pointed ends55

Length

7 amino acids

Organism or Origin

Synthetic derivative of human thymosin beta-4, whose full-length 43-amino-acid protein is abundant in mammalian tissues21279

Gene

TMSB4X

Sequence

N-terminus
Lys
Lys
Lys
Thr
Glu
Thr
Gln
C-terminus

KKKTETQ 12

Lysine, Lysine, Lysine, Threonine, Glutamic acid, Threonine, Glutamine

7 residuesapprox. 843.98 Dacharge +3 / -1 / net +2basic 3 • polar 3 • acidic 1

Sequence-derived properties

Length

7 residues

Molecular weight

862 Da

Average hydrophobicity

-2.87

Unique amino acids

4

Residue class composition

basic

3 (42.9%)

polar

3 (42.9%)

acidic

1 (14.3%)

Charge-category composition

neutral

3 (42.9%)

positive

3 (42.9%)

negative

1 (14.3%)

Amino acid composition

Lysine (Lys/K)

3 (42.9%)

Threonine (Thr/T)

2 (28.6%)

Glutamic acid (Glu/E)

1 (14.3%)

Glutamine (Gln/Q)

1 (14.3%)

Sources

  1. 2TB-500 (Thymosin Beta-4) | Peptide Biologix, https://peptidebiologix.com/tb-500
  2. 12Thymosin Beta-4 vs TB-500 | What to Know in 2024, https://www.peptidesciences.com/peptide-research/thymosin-beta-4-vs-tb-500
  3. 55Thymosin β4 Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed Ends†, https://pubs.acs.org/doi/abs/10.1021/bi970185v
  4. 79TMSB4X Gene: Function, Research, and Clinical Applications, https://learn.mapmygenome.in/genemap/tmsb4x

Related articles

BPC-157 vs TB-500 for Soft-Tissue RepairThymosin Beta-4

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Compiled from published literature and reference databases. See the editorial policy.

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