Function
TB-500 is a Signal peptide.
This Peptide is studied for enhancing musculoskeletal and cardiac repair, wound healing, and promoting cell migration and differentiation via actin cytoskeleton remodeling21255
Peptide record
TB-500
Peptide record
TB-500
Mechanism
TB-500 is a synthetic peptide comprising the LKKTETQ actin-binding motif of thymosin beta-4 that binds G-actin, sequesters actin monomers, and promotes cell migration, angiogenesis, and tissue repair1255
TB-500 is a Signaling modulator.
Receptor
Binds monomeric actin (G-actin) rather than a classical cell-surface receptor, modulating actin polymerization at barbed and pointed ends55
Length
7 amino acids
Organism or Origin
Synthetic derivative of human thymosin beta-4, whose full-length 43-amino-acid protein is abundant in mammalian tissues21279
Gene
TMSB4X
Sequence
KKKTETQ 12
Lysine, Lysine, Lysine, Threonine, Glutamic acid, Threonine, Glutamine
7 residuesapprox. 843.98 Dacharge +3 / -1 / net +2basic 3 • polar 3 • acidic 1
Sequence-derived properties
Length
7 residues
Molecular weight
862 Da
Average hydrophobicity
-2.87
Unique amino acids
4
Residue class composition
basic
3 (42.9%)
polar
3 (42.9%)
acidic
1 (14.3%)
Charge-category composition
neutral
3 (42.9%)
positive
3 (42.9%)
negative
1 (14.3%)
Amino acid composition
Lysine (Lys/K)
3 (42.9%)
Threonine (Thr/T)
2 (28.6%)
Glutamic acid (Glu/E)
1 (14.3%)
Glutamine (Gln/Q)
1 (14.3%)
Sources
- 2TB-500 (Thymosin Beta-4) | Peptide Biologix, https://peptidebiologix.com/tb-500
- 12Thymosin Beta-4 vs TB-500 | What to Know in 2024, https://www.peptidesciences.com/peptide-research/thymosin-beta-4-vs-tb-500
- 55Thymosin β4 Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed Ends†, https://pubs.acs.org/doi/abs/10.1021/bi970185v
- 79TMSB4X Gene: Function, Research, and Clinical Applications, https://learn.mapmygenome.in/genemap/tmsb4x