Mechanism
Synthetic peptide comprising the LKKTETQ actin-binding motif of thymosin beta-4 that binds G-actin, sequesters actin monomers, and promotes cell migration, angiogenesis, and tissue repair.1255
Peptide record
TB-500
Function
Studied for enhancing musculoskeletal and cardiac repair, wound healing, and promoting cell migration and differentiation via actin cytoskeleton remodeling.21255
Receptor
Binds monomeric actin (G-actin) rather than a classical cell-surface receptor, modulating actin polymerization at barbed and pointed ends.55
Sequence
Lys-Lys-Lys-Thr-Glu-Thr-Gln (LKKTETQ)12
Length
7 amino acids
Organism or Origin
Synthetic derivative of human thymosin beta-4, whose full-length 43-amino-acid protein is abundant in mammalian tissues.21279
Gene
TMSB4X
Sources
- 2TB-500 (Thymosin Beta-4) | Peptide Biologix, https://peptidebiologix.com/tb-500
- 12Thymosin Beta-4 vs TB-500 | What to Know in 2024, https://www.peptidesciences.com/peptide-research/thymosin-beta-4-vs-tb-500
- 55Thymosin β4 Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed Ends†, https://pubs.acs.org/doi/abs/10.1021/bi970185v
- 79TMSB4X Gene: Function, Research, and Clinical Applications, https://learn.mapmygenome.in/genemap/tmsb4x