peptable

Comparison

Setmelanotide vs TB-500

Function

While Setmelanotide is approved for chronic weight management in patients with POMC, PCSK1, LEPR deficiencies and Bardet–Biedl syndrome by reducing hunger and promoting weight loss92, TB-500 is studied for enhancing musculoskeletal and cardiac repair, wound healing, and promoting cell migration and differentiation via actin cytoskeleton remodeling21255.

Mechanism

While Setmelanotide works as a potent synthetic melanocortin-4 receptor (MC4R) agonist derived from a POMC/α-MSH–related sequence that restores downstream MC4R signaling in genetic obesity syndromes3192100, TB-500 is a synthetic peptide comprising the LKKTETQ actin-binding motif of thymosin beta-4 that binds G-actin, sequesters actin monomers, and promotes cell migration, angiogenesis, and tissue repair1255.

Length and Sequence

Setmelanotide is amino acids long, whereas TB-500 is longer as it has a length of 7 amino acids. Setmelanotide is made up of a sequence of sequence data not available in the current dataset. TB-500 is made up of a sequence of Lysine, Lysine, Lysine, Threonine, Glutamic acid, Threonine, Glutamine.

Receptor

Setmelanotide

Melanocortin-4 receptor (MC4R) 3192100

TB-500

Binds monomeric actin (G-actin) rather than a classical cell-surface receptor, modulating actin polymerization at barbed and pointed ends55

Organism or Origin

Setmelanotide

Synthetic analog of POMC-derived α-MSH peptide928190

TB-500

Synthetic derivative of human thymosin beta-4, whose full-length 43-amino-acid protein is abundant in mammalian tissues21279

Gene

Setmelanotide

POMC

TB-500

TMSB4X

Sources

31[PDF] 213793Orig1s000 - accessdata.fda.gov, https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/213793Orig1s000PharmR.pdf
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
92Setmelanotide, https://go.drugbank.com/drugs/DB11700
100Multiple Independent Sub-studies of Setmelanotide in, https://onderzoekmetmensen.nl/en/node/53452/pdf
2TB-500 (Thymosin Beta-4) | Peptide Biologix, https://peptidebiologix.com/tb-500
12Thymosin Beta-4 vs TB-500 | What to Know in 2024, https://www.peptidesciences.com/peptide-research/thymosin-beta-4-vs-tb-500
79TMSB4X Gene: Function, Research, and Clinical Applications, https://learn.mapmygenome.in/genemap/tmsb4x