Peptide record

Setmelanotide

Mechanism

Potent synthetic melanocortin-4 receptor (MC4R) agonist derived from a POMC/α-MSH–related sequence that restores downstream MC4R signaling in genetic obesity syndromes.31 92 100

Function

Approved for chronic weight management in patients with POMC, PCSK1, LEPR deficiencies and Bardet–Biedl syndrome by reducing hunger and promoting weight loss.92

Receptor

Melanocortin-4 receptor (MC4R). 31 92 100

Sequence

Synthetic peptide MC4R agonist with α-MSH–derived core; exact sequence is proprietary but characterized as a POMC-derived melanocortin analog.31 92 100

Length

null amino acids

Organism or Origin

Synthetic analog of POMC-derived α-MSH peptide.92 81 90

Gene

POMC

Sources

31[PDF] 213793Orig1s000 - accessdata.fda.gov, https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/213793Orig1s000PharmR.pdf
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
92Setmelanotide, https://go.drugbank.com/drugs/DB11700
100Multiple Independent Sub-studies of Setmelanotide in, https://onderzoekmetmensen.nl/en/node/53452/pdf

No related articles are linked to this peptide yet.