Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

Setmelanotide

Function

Setmelanotide is a Metabolic peptide.

This Peptide is approved for chronic weight management in patients with POMC, PCSK1, LEPR deficiencies and Bardet–Biedl syndrome by reducing hunger and promoting weight loss92

Mechanism

Setmelanotide is a potent synthetic melanocortin-4 receptor (MC4R) agonist derived from a POMC/α-MSH–related sequence that restores downstream MC4R signaling in genetic obesity syndromes3192100

Setmelanotide is a Receptor agonist.

Receptor

Melanocortin-4 receptor (MC4R) 3192100

Sequence note

Synthetic peptide MC4R agonist with α-MSH–derived core; exact sequence is proprietary but characterized as a POMC-derived melanocortin analog 3192100

Length

null amino acids

Organism or Origin

Synthetic analog of POMC-derived α-MSH peptide928190

Gene

POMC

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 31[PDF] 213793Orig1s000 - accessdata.fda.gov, https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/213793Orig1s000PharmR.pdf
  2. 81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
  3. 90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
  4. 92Setmelanotide, https://go.drugbank.com/drugs/DB11700
  5. 100Multiple Independent Sub-studies of Setmelanotide in, https://onderzoekmetmensen.nl/en/node/53452/pdf

Related articles

No related articles are linked to this peptide yet.