Comparison
While Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39, Thymosin Alpha-1 is clinically used in some countries as an immunomodulator for chronic hepatitis B/C and as an adjuvant in cancer therapy, enhancing cell-mediated immunity41487.
While Selank works as a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39, Thymosin Alpha-1 is a 28-amino-acid thymic peptide fragment of prothymosin alpha that activates dendritic cells and T cells primarily via TLR9/MyD88/NF-κB signaling, enhancing Th1 responses and NK-cell cytotoxicity414.
Selank is 7 amino acids long, whereas Thymosin Alpha-1 is longer as it has a length of 28 amino acids. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline. Thymosin Alpha-1 is made up of a sequence of Serine, Aspartic acid, Alanine, Alanine, Valine, Aspartic acid, Threonine, Serine, Serine, Glutamic acid, Isoleucine, Threonine, Threonine, Lysine, Aspartic acid, Leucine, Lysine, Glutamic acid, Lysine, Lysine, Glutamic acid, Valine, Valine, Glutamic acid, Glutamic acid, Alanine, Glutamic acid, Asparagine.
Selank
Not clearly established in the current dataset.
Thymosin Alpha-1
Toll-like receptors, predominantly TLR9 (and also TLR2/TLR3) on plasmacytoid dendritic cells and other immune cells4
Selank
Not assigned in the current dataset.
Thymosin Alpha-1
PTMA
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