Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Alanine

Ala / A · hydrophobic residue · neutral charge

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Arginine

Arg / R · basic residue · positive charge

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Asparagine

Asn / N · polar residue · neutral charge

Aspartic acid

Asp / D · acidic residue · negative charge

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide record

Thymosin Alpha-1

Peptide record

Thymosin Alpha-1

Function

Thymosin Alpha-1 is a Immune-modulating peptide.

This Peptide is clinically used in some countries as an immunomodulator for chronic hepatitis B/C and as an adjuvant in cancer therapy, enhancing cell-mediated immunity4 14 87

Mechanism

Thymosin Alpha-1 is a 28-amino-acid thymic peptide fragment of prothymosin alpha that activates dendritic cells and T cells primarily via TLR9/MyD88/NF-κB signaling, enhancing Th1 responses and NK-cell cytotoxicity4 14

Thymosin Alpha-1 is a Signaling modulator.

Receptor

Toll-like receptors, predominantly TLR9 (and also TLR2/TLR3) on plasmacytoid dendritic cells and other immune cells4

Length

28 amino acids

Organism or Origin

Endogenous fragment of human prothymosin alpha produced in the thymus14 87

Gene

PTMA

Sequence

AcN-terminus

C-terminusOH

Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH 14

Serine, Aspartic acid, Alanine, Alanine, Valine, Aspartic acid, Threonine, Serine, Serine, Glutamic acid, Isoleucine, Threonine, Threonine, Lysine, Aspartic acid, Leucine, Lysine, Glutamic acid, Lysine, Lysine, Glutamic acid, Valine, Valine, Glutamic acid, Glutamic acid, Alanine, Glutamic acid, Asparagine

28 residuesapprox. 3048.29 Dacharge +4 / -9 / net -5polar 7 • acidic 9 • hydrophobic 8 • basic 4

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sources

4Thymosin Alpha-1: Thymic Immunomodulatory Peptide and ..., https://peptpedia.org/research/thymosin-alpha1-t-cell-immunomodulation
14Thymosin Alpha 1 - CPC Scientific, https://cpcscientific.com/products/catalog-peptides/THYM-004/
87PTMA protein | Thymosin alpha 1 Protein-NP_001092755.1, https://www.mybiosource.com/ptma-protein/thymosin-alpha-1/846997

Related articles

No related articles are linked to this peptide yet.