Mechanism
28-amino-acid thymic peptide fragment of prothymosin alpha that activates dendritic cells and T cells primarily via TLR9/MyD88/NF-κB signaling, enhancing Th1 responses and NK-cell cytotoxicity.414
Peptide record
Thymosin Alpha-1
Function
Clinically used in some countries as an immunomodulator for chronic hepatitis B/C and as an adjuvant in cancer therapy, enhancing cell-mediated immunity.41487
Receptor
Toll-like receptors, predominantly TLR9 (and also TLR2/TLR3) on plasmacytoid dendritic cells and other immune cells.4
Sequence
Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN)14
Length
28 amino acids
Organism or Origin
Endogenous fragment of human prothymosin alpha produced in the thymus.1487
Gene
PTMA
Sources
- 4Thymosin Alpha-1: Thymic Immunomodulatory Peptide and ..., https://peptpedia.org/research/thymosin-alpha1-t-cell-immunomodulation
- 14Thymosin Alpha 1 - CPC Scientific, https://cpcscientific.com/products/catalog-peptides/THYM-004/
- 87PTMA protein | Thymosin alpha 1 Protein-NP_001092755.1, https://www.mybiosource.com/ptma-protein/thymosin-alpha-1/846997
Related articles
No related articles are linked to this peptide yet.