Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Selank works as a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Selank
Not assigned in the current dataset.
SS-31
Not assigned in the current dataset.
The clearest overlap between Selank and SS-31 is that both converge around Signaling modulator. Their typical research and application settings separate fairly clearly: Selank is more often discussed in the realm of Neurology and brain health and Immunology and inflammation, whereas SS-31 is more often associated with the realm of Aging and longevity and Cardiovascular health. Both appear to work through Signaling modulator, but the functional emphasis still separates, with Selank leaning toward Anxiolytic and sleep modulation and Immune regulation and SS-31 leaning toward Mitochondrial function modulation, Antioxidant activity, and Neuroprotection and cognition. Selank has a more synthetic analog origin, while SS-31 is closer to synthetic design background with Selank approved for Research use only and SS-31 in Clinical phase 2. SS-31 incorporates d-amino acid substitution and amidation features that are not part of Selank, while their sequence patterns also diverge, with Selank showing proline-rich features and SS-31 showing cationic amphipathic features.
No related articles are linked to these peptides yet.