Comparison
While Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Selank works as a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Selank is 7 amino acids long, whereas SS-31 is shorter as it has a length of 4 amino acids. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.
Selank
Not assigned in the current dataset.
SS-31
Not assigned in the current dataset.
No related articles are linked to these peptides yet.