Comparison
While PT-141 is FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and is studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways42101, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While PT-141 works as the synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal3242101, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
PT-141 is 7 amino acids long, whereas SS-31 is shorter as it has a length of 4 amino acids. PT-141 is made up of a sequence of sequence data not available in the current dataset. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.
PT-141
POMC
SS-31
Not assigned in the current dataset.
No related articles are linked to these peptides yet.