Peptable

Peptide record

PT-141

Function

PT-141 is a Neuropeptide.

This Peptide is FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and is studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways42101

Mechanism

PT-141 is the synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal3242101

PT-141 is a Neurotransmitter modulator.

Receptor

Melanocortin receptors, with highest functional relevance at MC4R and MC3R; also binds MC1R and MC5R3242

Sequence note

Cyclic melanocortin analog structurally related to α-MSH; often represented as a shortened, modified α-MSH sequence (exact residue sequence is available in specialist monographs) 42

Length

7 amino acids

Organism or Origin

Synthetic analog of human α-MSH derived from POMC428190

Gene

POMC

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 32PT-141 (Bremelanotide): Research Applications and Quality ..., https://wheretofindpeptides.com/research/pt-141-bremelanotide-research-applications-and-quality-assessment-1
  2. 42[PDF] The Discovery and Development of Bremelanotide (PT-141), https://www.benchchem.com/pdf/The_Discovery_and_Development_of_Bremelanotide_PT_141_A_Technical_Guide.pdf
  3. 81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
  4. 90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
  5. 101PT-141 (Bremelanotide Acetate): Clinical Overview, Uses ... - eNavvi, https://enavvi.com/insights/pt-141-bremelanotide-for-sexual-dysfunction-clinical-guide-for-physicians

Related articles

No related articles are linked to this peptide yet.

About this page

Published by
Peptable, as a structured reference dataset.
Dataset updated
Sourcing
Compiled from published literature and reference databases. See the editorial policy.

This page is reference information, not medical advice, and describes no dosages or administration protocols. Read the full disclaimer.