Peptide record

PT-141

Mechanism

Synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal.32 42 101

Function

FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways.42 101

Receptor

Melanocortin receptors, with highest functional relevance at MC4R and MC3R; also binds MC1R and MC5R.32 42

Sequence

Cyclic melanocortin analog structurally related to α-MSH; often represented as a shortened, modified α-MSH sequence (exact residue sequence is available in specialist monographs). 42

Length

7 amino acids

Organism or Origin

Synthetic analog of human α-MSH derived from POMC.42 81 90

Gene

POMC

Sources

32PT-141 (Bremelanotide): Research Applications and Quality ..., https://wheretofindpeptides.com/research/pt-141-bremelanotide-research-applications-and-quality-assessment-1
42[PDF] The Discovery and Development of Bremelanotide (PT-141), https://www.benchchem.com/pdf/The_Discovery_and_Development_of_Bremelanotide_PT_141_A_Technical_Guide.pdf
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
101PT-141 (Bremelanotide Acetate): Clinical Overview, Uses ... - eNavvi, https://enavvi.com/insights/pt-141-bremelanotide-for-sexual-dysfunction-clinical-guide-for-physicians

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