Peptable

Peptide record

PT-141

Function

PT-141 is a Neuropeptide.

This Peptide is FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and is studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways42101

Mechanism

PT-141 is the synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal3242101

PT-141 is a Neurotransmitter modulator.

Receptor

Melanocortin receptors, with highest functional relevance at MC4R and MC3R; also binds MC1R and MC5R3242

Sequence note

Cyclic melanocortin analog structurally related to α-MSH; often represented as a shortened, modified α-MSH sequence (exact residue sequence is available in specialist monographs) 42

Length

7 amino acids

Organism or Origin

Synthetic analog of human α-MSH derived from POMC428190

Gene

POMC

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 32PT-141 (Bremelanotide): Research Applications and Quality ..., https://wheretofindpeptides.com/research/pt-141-bremelanotide-research-applications-and-quality-assessment-1
  2. 42[PDF] The Discovery and Development of Bremelanotide (PT-141), https://www.benchchem.com/pdf/The_Discovery_and_Development_of_Bremelanotide_PT_141_A_Technical_Guide.pdf
  3. 81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
  4. 90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
  5. 101PT-141 (Bremelanotide Acetate): Clinical Overview, Uses ... - eNavvi, https://enavvi.com/insights/pt-141-bremelanotide-for-sexual-dysfunction-clinical-guide-for-physicians

Related articles

No related articles are linked to this peptide yet.