Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While PT-141 is FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and is studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways42101, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While PT-141 works as the synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal3242101, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
PT-141
POMC
Selank
Not assigned in the current dataset.
Both peptides fall into a similar broad context as Neuropeptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: PT-141 is more often discussed in the realm of Reproductive health, whereas Selank is more often associated with the realm of Neurology and brain health and Immunology and inflammation. Mechanistically, both point toward Neurotransmitter modulator and Signaling modulator and converge on GPCR receptor, although the downstream emphasis is not identical. Both are synthetic in origin and their development context also differs, with PT-141 approved while Selank is approved for Research use only. PT-141 takes the form of a cyclic peptide, whereas Selank is closer to a linear peptide, PT-141 incorporates acetylation features that are not part of Selank; while their sequence patterns also diverge, with PT-141 showing protein-mimetic sequence features and Selank showing proline-rich features.
No related articles are linked to these peptides yet.