Comparison
While MGF is upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects22138, TB-500 is studied for enhancing musculoskeletal and cardiac repair, wound healing, and promoting cell migration and differentiation via actin cytoskeleton remodeling21255.
While MGF works as a 24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy22138144, TB-500 is a synthetic peptide comprising the LKKTETQ actin-binding motif of thymosin beta-4 that binds G-actin, sequesters actin monomers, and promotes cell migration, angiogenesis, and tissue repair1255.
MGF is 24 amino acids long, whereas TB-500 is shorter as it has a length of 7 amino acids. MGF is made up of a sequence of Tyrosine, Glutamine, Proline, Proline, Serine, Threonine, Asparagine, Lysine, Asparagine, Threonine, Lysine, Serine, Glutamine, Arginine, Arginine, Lysine, Glycine, Serine, Threonine, Phenylalanine, Glutamic acid, Glutamic acid, Arginine, Lysine. TB-500 is made up of a sequence of Lysine, Lysine, Lysine, Threonine, Glutamic acid, Threonine, Glutamine.
MGF
IGF1
TB-500
TMSB4X