Mechanism
24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy.22138144
Peptide record
MGF
Function
Upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects.22138
Receptor
Sequence
Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys (YQPPSTNKNTKSQRRKGSTFEERK)22
Length
24 amino acids
Organism or Origin
Gene
IGF1
Sources
- 22Mechano growth factor - Wikipedia, https://en.wikipedia.org/wiki/Mechano_growth_factor
- 97IGF1 Gene - Insulin Like Growth Factor 1, https://www.genecards.org/cgi-bin/carddisp.pl?gene=IGF1
- 134Insulin-like growth factor 1 receptor - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1_receptor
- 138A Splice Variant of IGF-1 within the Growth Plate | PLOS One, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076133
- 139IGF1 receptor signaling pathways, https://pubmed.ncbi.nlm.nih.gov/29535161/
- 144Insulin-like growth factor 1 - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1
Related articles
No related articles are linked to this peptide yet.