Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Alanine

Ala / A · hydrophobic residue · neutral charge

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Arginine

Arg / R · basic residue · positive charge

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Asparagine

Asn / N · polar residue · neutral charge

Aspartic acid

Asp / D · acidic residue · negative charge

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide record

MGF

Peptide record

MGF

Function

MGF is a Signal peptide.

This Peptide is upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects22 138

Mechanism

MGF is a 24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy22 138 144

MGF is a Growth factor mimetic.

Receptor

Insulin-like growth factor 1 receptor (IGF1R) 134 139

Length

24 amino acids

Organism or Origin

Endogenous human IGF-1 splice variant (IGF-1Ec) 22 138 97

Gene

IGF1

Sequence

N-terminus

C-terminus

YQPPSTNKNTKSQRRKGSTFEERK 22

Tyrosine, Glutamine, Proline, Proline, Serine, Threonine, Asparagine, Lysine, Asparagine, Threonine, Lysine, Serine, Glutamine, Arginine, Arginine, Lysine, Glycine, Serine, Threonine, Phenylalanine, Glutamic acid, Glutamic acid, Arginine, Lysine

24 residuesapprox. 2850.17 Dacharge +7 / -2 / net +5polar 11 • special 3 • basic 7 • hydrophobic 1 • acidic 2

Sequence-derived properties

Length

24 residues

Molecular weight

2868.19 Da

Average hydrophobicity

-2.36

Unique amino acids

11

Residue class composition

polar

11 (45.8%)

basic

7 (29.2%)

special

3 (12.5%)

acidic

2 (8.3%)

hydrophobic

1 (4.2%)

Charge-category composition

neutral

15 (62.5%)

positive

7 (29.2%)

negative

2 (8.3%)

Amino acid composition

Lysine (Lys/K)

4 (16.7%)

Arginine (Arg/R)

3 (12.5%)

Serine (Ser/S)

3 (12.5%)

Threonine (Thr/T)

3 (12.5%)

Asparagine (Asn/N)

2 (8.3%)

Glutamic acid (Glu/E)

2 (8.3%)

Glutamine (Gln/Q)

2 (8.3%)

Proline (Pro/P)

2 (8.3%)

Glycine (Gly/G)

1 (4.2%)

Phenylalanine (Phe/F)

1 (4.2%)

Tyrosine (Tyr/Y)

1 (4.2%)

Sources

22Mechano growth factor - Wikipedia, https://en.wikipedia.org/wiki/Mechano_growth_factor
97IGF1 Gene - Insulin Like Growth Factor 1, https://www.genecards.org/cgi-bin/carddisp.pl?gene=IGF1
134Insulin-like growth factor 1 receptor - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1_receptor
138A Splice Variant of IGF-1 within the Growth Plate | PLOS One, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076133
139IGF1 receptor signaling pathways, https://pubmed.ncbi.nlm.nih.gov/29535161/
144Insulin-like growth factor 1 - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1

Related articles

No related articles are linked to this peptide yet.