Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, MGF is upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects22138.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, MGF is a 24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy22138144.
Matrixyl is 5 amino acids long, whereas MGF is longer as it has a length of 24 amino acids. Matrixyl is made up of a sequence of Lysine, Threonine, Threonine, Lysine, Serine. MGF is made up of a sequence of Tyrosine, Glutamine, Proline, Proline, Serine, Threonine, Asparagine, Lysine, Asparagine, Threonine, Lysine, Serine, Glutamine, Arginine, Arginine, Lysine, Glycine, Serine, Threonine, Phenylalanine, Glutamic acid, Glutamic acid, Arginine, Lysine.
Matrixyl
Not assigned in the current dataset.
MGF
IGF1
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