Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, MGF is upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects22138.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, MGF is a 24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy22138144.
Matrixyl
Not assigned in the current dataset.
MGF
IGF1
Both peptides fall into a similar broad context as Signal peptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: Matrixyl is more often discussed in the realm of Dermatology and aesthetics, whereas MGF is more often associated with the realm of Musculoskeletal health. Their biological logic is quite different: Matrixyl is a matrix remodeling modulator, whereas MGF is a growth factor mimetic and a signaling modulator. Matrixyl has a more synthetic design origin, while MGF is closer to natural endogenous background and their development context also differs, with Matrixyl cosmetic grade while MGF is in Preclinical development. Matrixyl takes the form of a peptide conjugate, whereas MGF is closer to a linear peptide, while Matrixyl incorporates palmitoylation features that are not part of MGF.
No related articles are linked to these peptides yet.