Comparison
While KPV is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While KPV works as the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
KPV is 3 amino acids long, whereas SS-31 is longer as it has a length of 4 amino acids. KPV is made up of a sequence of Lysine, Proline, Valine. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.
KPV
SS-31
KPV
POMC
SS-31
Not assigned in the current dataset.
No related articles are linked to these peptides yet.