Peptide record

KPV

Mechanism

C-terminal Lys-Pro-Val tripeptide fragment of α-MSH that exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation.6 84

Function

Investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair.6 84

Receptor

No single primary receptor; the KPV motif can influence melanocortin receptor binding profiles (MC1R–MC5R), but many anti-inflammatory effects appear melanocortin-independent.6 84

Sequence

Lys-Pro-Val (KPV)84

Length

3 amino acids

Organism or Origin

Endogenous tripeptide corresponding to positions 11–13 of human α-MSH.84 90

Gene

POMC

Sources

6Keratinocyte And Dermal..., https://oathresearch.com/2026/03/27/kpv-tripeptide-nfkb-inhibition-anti-inflammatory-mechanisms-cell-culture/
84KPV: Comprehensive Research Monograph and Technical ..., https://peptidebiologix.com/kpv
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/

No related articles are linked to this peptide yet.