Function

KPV is a Immune-modulating peptide.

This Peptide is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684

Mechanism

KPV is the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684

KPV is a Signaling modulator.

Receptor

No single primary receptor; the KPV motif can influence melanocortin receptor binding profiles (MC1R–MC5R), but many anti-inflammatory effects appear melanocortin-independent684

Length

3 amino acids

Organism or Origin

Endogenous tripeptide corresponding to positions 11–13 of human α-MSH8490

Gene

POMC