Comparison
While KPV is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684, Melanotan I is approved in some regions for prevention of phototoxicity in erythropoietic protoporphyria and is studied as a skin-darkening, photoprotective peptide3444.
While KPV works as the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684, Melanotan I is a linear 13-amino-acid analog of α-MSH (afamelanotide) that selectively activates MC1R on melanocytes, increasing eumelanin synthesis and providing photoprotection3444.
KPV is 3 amino acids long, whereas Melanotan I is longer as it has a length of 13 amino acids. KPV is made up of a sequence of Lysine, Proline, Valine. Melanotan I is made up of a sequence of Serine, Tyrosine, Serine, Nle, Glutamic acid, Histidine, Phenylalanine, Arginine, Tryptophan, Glycine, Lysine, Proline, Valine.
KPV
POMC
Melanotan I
POMC
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