Peptide record

Melanotan I

Mechanism

Linear 13-amino-acid analog of α-MSH (afamelanotide) that selectively activates MC1R on melanocytes, increasing eumelanin synthesis and providing photoprotection.34 44

Function

Approved in some regions for prevention of phototoxicity in erythropoietic protoporphyria and studied as a skin-darkening, photoprotective peptide.34 44

Receptor

Melanocortin-1 receptor (MC1R). 34 44 81

Sequence

Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 (Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2).34 44

Length

13 amino acids

Organism or Origin

Synthetic analog of human α-MSH derived from POMC.34 44 81 90

Gene

POMC

Sources

34Melanotan I (Afamelanotide): Research Profile - PeptideJournal, https://www.peptidejournal.org/peptides/melanotan-i-research-profile
44Melanotan I: properties, applications and references, https://www.benchchem.com/zh/product/b1666627
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/

No related articles are linked to this peptide yet.