Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Alanine

Ala / A · hydrophobic residue · neutral charge

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Arginine

Arg / R · basic residue · positive charge

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Asparagine

Asn / N · polar residue · neutral charge

Aspartic acid

Asp / D · acidic residue · negative charge

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide record

Melanotan I

Peptide record

Melanotan I

Function

Melanotan I is a Hormone peptide.

This Peptide is approved in some regions for prevention of phototoxicity in erythropoietic protoporphyria and is studied as a skin-darkening, photoprotective peptide34 44

Mechanism

Melanotan I is a linear 13-amino-acid analog of α-MSH (afamelanotide) that selectively activates MC1R on melanocytes, increasing eumelanin synthesis and providing photoprotection34 44

Melanotan I is a Receptor agonist.

Receptor

Melanocortin-1 receptor (MC1R) 34 44 81

Length

13 amino acids

Organism or Origin

Synthetic analog of human α-MSH derived from POMC34 44 81 90

Gene

POMC

Sequence

AcN-terminus

C-terminusNH2

Ac-S-Y-S-Nle-E-H-D-F-R-W-G-K-P-V-NH2 34 44

Serine, Tyrosine, Serine, Nle, Glutamic acid, Histidine, Phenylalanine, Arginine, Tryptophan, Glycine, Lysine, Proline, Valine

13 residuesapprox. 1474.65 Dacharge +3 / -1 / net +2polar 3 • acidic 1 • basic 3 • hydrophobic 3 • special 21 residues without standard metadata

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sequence-derived properties are omitted because one or more residues are not present in the standard amino-acid dataset.

Sources

34Melanotan I (Afamelanotide): Research Profile - PeptideJournal, https://www.peptidejournal.org/peptides/melanotan-i-research-profile
44Melanotan I: properties, applications and references, https://www.benchchem.com/zh/product/b1666627
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/

Related articles

No related articles are linked to this peptide yet.