Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While KPV is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684, LL-37 acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215.
While KPV works as the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684, LL-37 is a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586.
KPV
LL-37
KPV
POMC
LL-37
CAMP
Both peptides fall into a similar broad context as Immune-modulating peptides, although the details of how they are used and discussed still diverge. Both are often discussed in Immunology and inflammation and Gastroenterology contexts, while KPV is more of a signal peptide and LL-37 is better described as a antimicrobial peptide. Both appear to work through Signaling modulator, but the functional emphasis still separates, with KPV leaning toward Anti-inflammatory and LL-37 leaning toward Anti-pathogenic and Tissue repair and healing. Both come from biologically derived origins and both are still best understood as being in Preclinical development. Their sequence patterns also diverge, with KPV showing protein-mimetic sequence features and LL-37 showing cationic amphipathic and alpha-helical domain features.
No related articles are linked to these peptides yet.