Mechanism
Cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation.521586
Peptide record
LL-37
Function
Acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts.5215
Receptor
Functions as a ligand for CXCR2 on neutrophils and other myeloid cells; LL-37 signaling has also been linked to FPR2 and P2X7 in various cell types.515
Sequence
Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser (LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES)86
Length
37 amino acids
Organism or Origin
Human cathelicidin antimicrobial peptide generated from the CAP-18 precursor.5286
Gene
CAMP
Sources
- 5Evidence that cathelicidin peptide LL‐37 may act as a functional ligand for CXCR2 on human neutrophils, https://onlinelibrary.wiley.com/doi/full/10.1002/eji.200939496
- 15The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485164/
- 52Cathelicidin LL-37: A new important molecule in the ... - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC7388365/
- 86Cathelicidin antimicrobial peptide - Wikipedia, https://en.wikipedia.org/wiki/Cathelicidin_antimicrobial_peptide
Related articles
No related articles are linked to this peptide yet.