Peptable

Peptide record

LL-37

Function

LL-37 is a Antimicrobial peptide.

This Peptide acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215

Mechanism

LL-37 is a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586

LL-37 is a Membrane disruptor.

Receptor

Functions as a ligand for CXCR2 on neutrophils and other myeloid cells; LL-37 signaling has also been linked to FPR2 and P2X7 in various cell types515

Length

37 amino acids

Organism or Origin

Human cathelicidin antimicrobial peptide generated from the CAP-18 precursor5286

Gene

CAMP

Sequence

LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 86

Leucine, Leucine, Glycine, Aspartic acid, Phenylalanine, Phenylalanine, Arginine, Lysine, Serine, Lysine, Glutamic acid, Lysine, Isoleucine, Glycine, Lysine, Glutamic acid, Phenylalanine, Lysine, Arginine, Isoleucine, Valine, Glutamine, Arginine, Isoleucine, Lysine, Aspartic acid, Phenylalanine, Leucine, Arginine, Asparagine, Leucine, Valine, Proline, Arginine, Threonine, Glutamic acid, Serine

37 residuesapprox. 4475.33 Dacharge +11 / -5 / net +6hydrophobic 13 • special 3 • acidic 5 • basic 11 • polar 5

Sequence-derived properties

Length

37 residues

Molecular weight

4493.34 Da

Average hydrophobicity

-0.72

Unique amino acids

14

Residue class composition

hydrophobic

13 (35.1%)

basic

11 (29.7%)

acidic

5 (13.5%)

polar

5 (13.5%)

special

3 (8.1%)

Charge-category composition

neutral

21 (56.8%)

positive

11 (29.7%)

negative

5 (13.5%)

Amino acid composition

Lysine (Lys/K)

6 (16.2%)

Arginine (Arg/R)

5 (13.5%)

Leucine (Leu/L)

4 (10.8%)

Phenylalanine (Phe/F)

4 (10.8%)

Glutamic acid (Glu/E)

3 (8.1%)

Isoleucine (Ile/I)

3 (8.1%)

Aspartic acid (Asp/D)

2 (5.4%)

Glycine (Gly/G)

2 (5.4%)

Serine (Ser/S)

2 (5.4%)

Valine (Val/V)

2 (5.4%)

Asparagine (Asn/N)

1 (2.7%)

Glutamine (Gln/Q)

1 (2.7%)

Proline (Pro/P)

1 (2.7%)

Threonine (Thr/T)

1 (2.7%)

Sources

  1. 5Evidence that cathelicidin peptide LL‐37 may act as a functional ligand for CXCR2 on human neutrophils, https://onlinelibrary.wiley.com/doi/full/10.1002/eji.200939496
  2. 15The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485164/
  3. 52Cathelicidin LL-37: A new important molecule in the ... - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC7388365/
  4. 86Cathelicidin antimicrobial peptide - Wikipedia, https://en.wikipedia.org/wiki/Cathelicidin_antimicrobial_peptide

Related articles

No related articles are linked to this peptide yet.