Comparison
While Kisspeptin is a key regulator of the hypothalamic–pituitary–gonadal axis, controlling puberty and fertility; kisspeptin-10 also inhibits trophoblast invasion and tumor metastasis in experimental models339199, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While Kisspeptin works as a family of peptides (eg, kisspeptin-10, -13, -14, -54) derived from the KISS1 precursor that activate G-protein–coupled receptor KISS1R (GPR54), triggering GnRH release and regulating pubertal onset and reproductive axis activity339199, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
Kisspeptin is 10 amino acids long, whereas Selank is shorter as it has a length of 7 amino acids. Kisspeptin is made up of a sequence of Tyrosine, Asparagine, Tryptophan, Asparagine, Serine, Phenylalanine, Glycine, Leucine, Arginine, Tyrosine. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.
Kisspeptin
KISS1
Selank
Not assigned in the current dataset.