Peptable

Peptide record

Kisspeptin

Function

Kisspeptin is a Hormone peptide.

This Peptide is a key regulator of the hypothalamic–pituitary–gonadal axis, controlling puberty and fertility; kisspeptin-10 also inhibits trophoblast invasion and tumor metastasis in experimental models339199

Mechanism

Kisspeptin is a family of peptides (eg, kisspeptin-10, -13, -14, -54) derived from the KISS1 precursor that activate G-protein–coupled receptor KISS1R (GPR54), triggering GnRH release and regulating pubertal onset and reproductive axis activity339199

Kisspeptin is a Receptor agonist.

Receptor

KISS1R (GPR54) kisspeptin receptor33919943

Length

10 amino acids

Organism or Origin

Endogenous human peptide products of the KISS1 gene9199

Gene

KISS1

Sequence

N-terminusC-terminusNH2

YNWNSFGLRY-NH2 7033

Tyrosine, Asparagine, Tryptophan, Asparagine, Serine, Phenylalanine, Glycine, Leucine, Arginine, Tyrosine

10 residuesapprox. 1301.43 Dacharge +1 / -0 / net +1polar 5 • hydrophobic 3 • special 1 • basic 1

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sources

  1. 33Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/15020672/
  2. 43Kisspeptin-10: Uses, Interactions, Mechanism of Action | DrugBank, https://go.drugbank.com/drugs/DB16210
  3. 70Kisspeptin-10, rat, https://pubchem.ncbi.nlm.nih.gov/compound/Kisspeptin-10_-rat
  4. 91Kisspeptin - Wikipedia, https://en.wikipedia.org/wiki/Kisspeptin
  5. 99Kisspeptin-1 - an overview, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/kisspeptin-1

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