Mechanism
Family of peptides (e.g., kisspeptin-10, -13, -14, -54) derived from the KISS1 precursor that activate G-protein–coupled receptor KISS1R (GPR54), triggering GnRH release and regulating pubertal onset and reproductive axis activity.339199
Peptide record
Kisspeptin
Function
Key regulator of hypothalamic–pituitary–gonadal axis, controlling puberty and fertility; kisspeptin-10 also inhibits trophoblast invasion and tumor metastasis in experimental models.339199
Receptor
Sequence
Kisspeptin-10 sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2 (YNWNSFGLRY).7033
Length
10 amino acids
Organism or Origin
Gene
KISS1
Sources
- 33Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/15020672/
- 43Kisspeptin-10: Uses, Interactions, Mechanism of Action | DrugBank, https://go.drugbank.com/drugs/DB16210
- 70Kisspeptin-10, rat, https://pubchem.ncbi.nlm.nih.gov/compound/Kisspeptin-10_-rat
- 91Kisspeptin - Wikipedia, https://en.wikipedia.org/wiki/Kisspeptin
- 99Kisspeptin-1 - an overview, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/kisspeptin-1