Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, Tesamorelin is FDA-approved to reduce excess visceral adipose tissue in HIV-associated lipodystrophy and is studied for broader body-composition, NAFLD, and cognitive effects via GH/IGF-1 axis modulation1893.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, Tesamorelin is a full-length 44-amino-acid GHRH analog with an N-terminal trans-3-hexenoic acid modification that binds GHRHR, activating cAMP/PKA signaling to increase endogenous GH and IGF-1, with improved stability versus native GHRH182893102.
Epitalon
Not assigned in the current dataset.
Tesamorelin
GHRH
Epitalon and Tesamorelin are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Epitalon is more often discussed in the realm of Aging and longevity, whereas Tesamorelin is more often associated with the realm of Metabolic and endocrine and Cardiovascular health. Their biological logic is quite different: Epitalon is a signaling modulator and a gene expression modulator, whereas Tesamorelin is a receptor agonist. Both are synthetic in origin and their development context also differs, with Epitalon approved for Research use only while Tesamorelin is approved. Epitalon takes the form of a linear peptide, whereas Tesamorelin is closer to a peptide conjugate, while Tesamorelin incorporates amidation features that are not part of Epitalon.
No related articles are linked to these peptides yet.