Mechanism
Full-length 44-amino-acid GHRH analog with an N-terminal trans-3-hexenoic acid modification that binds GHRHR, activating cAMP/PKA signaling to increase endogenous GH and IGF-1, with improved stability versus native GHRH.182893102
Peptide record
Tesamorelin
Function
FDA-approved to reduce excess visceral adipose tissue in HIV-associated lipodystrophy and studied for broader body-composition, NAFLD, and cognitive effects via GH/IGF-1 axis modulation.1893
Receptor
Sequence
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH228102
Length
44 amino acids
Organism or Origin
Gene
GHRH
Sources
- 18Tesamorelin: Benefits, Dosing & Where to Buy (2026) - Peptides, https://thepeptidecatalog.com/peptides/tesamorelin
- 28The Ultimate Guide to Tesamorelin | Las Vegas | Sky Health, https://www.skyhealthnv.com/tesamorelin
- 93Tesamorelin - FDA-Approved GHRH Analog Guide - PeptideMark, https://www.peptidemark.com/peptides/tesamorelin
- 94Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth-hormone-releasing_hormone_receptor
- 102Tesamorelin: Molecular Characterization and Metabolic Research, https://biotechpeptides.com/2026/03/25/tesamorelin-molecular-characterization-growth-hormone-axis-modulation-and-metabolic-research/
- 103Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone_receptor
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