Peptable

Peptide record

Tesamorelin

Function

Tesamorelin is a Hormone peptide.

This Peptide is FDA-approved to reduce excess visceral adipose tissue in HIV-associated lipodystrophy and is studied for broader body-composition, NAFLD, and cognitive effects via GH/IGF-1 axis modulation1893

Mechanism

Tesamorelin is a full-length 44-amino-acid GHRH analog with an N-terminal trans-3-hexenoic acid modification that binds GHRHR, activating cAMP/PKA signaling to increase endogenous GH and IGF-1, with improved stability versus native GHRH182893102

Tesamorelin is a Receptor agonist.

Receptor

Growth hormone–releasing hormone receptor (GHRHR) 9394103

Length

44 amino acids

Organism or Origin

Synthetic analog of human hypothalamic GHRH1893

Gene

GHRH

Sequence

YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2 28102

Tyrosine, Alanine, Aspartic acid, Alanine, Isoleucine, Phenylalanine, Threonine, Asparagine, Serine, Tyrosine, Arginine, Lysine, Valine, Leucine, Glycine, Glutamine, Leucine, Serine, Alanine, Arginine, Lysine, Leucine, Leucine, Glutamine, Aspartic acid, Isoleucine, Methionine, Serine, Arginine, Glutamine, Glutamine, Glycine, Glutamic acid, Serine, Asparagine, Glutamine, Glutamic acid, Arginine, Glycine, Alanine, Arginine, Alanine, Arginine, Leucine

44 residuesapprox. 5022.71 Dacharge +8 / -4 / net +4polar 14 • hydrophobic 15 • acidic 4 • basic 8 • special 3

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sources

  1. 18Tesamorelin: Benefits, Dosing & Where to Buy (2026) - Peptides, https://thepeptidecatalog.com/peptides/tesamorelin
  2. 28The Ultimate Guide to Tesamorelin | Las Vegas | Sky Health, https://www.skyhealthnv.com/tesamorelin
  3. 93Tesamorelin - FDA-Approved GHRH Analog Guide - PeptideMark, https://www.peptidemark.com/peptides/tesamorelin
  4. 94Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth-hormone-releasing_hormone_receptor
  5. 102Tesamorelin: Molecular Characterization and Metabolic Research, https://biotechpeptides.com/2026/03/25/tesamorelin-molecular-characterization-growth-hormone-axis-modulation-and-metabolic-research/
  6. 103Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone_receptor

Related articles

No related articles are linked to this peptide yet.