Function
Epitalon is a Neuropeptide.
This Peptide is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36
Peptide record
Epitalon
Peptide record
Epitalon
Mechanism
Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36
Epitalon is a Signaling modulator.
Receptor
Binds nuclear histone proteins (H1, H2B, H3, H4) rather than a classic membrane receptor36
Length
4 amino acids
Organism or Origin
Synthetic peptide modeled after a pineal gland peptide fraction; not directly encoded as a standalone peptide in humans36
Gene
Not assigned in the current dataset.
Sequence
AEDG 36
Alanine, Glutamic acid, Aspartic acid, Glycine
4 residuesapprox. 372.34 Dacharge +0 / -2 / net -2hydrophobic 1 • acidic 2 • special 1
Sequence-derived properties
Length
4 residues
Molecular weight
390.35 Da
Average hydrophobicity
-1.4
Unique amino acids
4
Residue class composition
acidic
2 (50%)
hydrophobic
1 (25%)
special
1 (25%)
Charge-category composition
negative
2 (50%)
neutral
2 (50%)
Amino acid composition
Alanine (Ala/A)
1 (25%)
Aspartic acid (Asp/D)
1 (25%)
Glutamic acid (Glu/E)
1 (25%)
Glycine (Gly/G)
1 (25%)
Sources
- 36AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/
Related articles
No related articles are linked to this peptide yet.