Comparison

Epitalon vs Sermorelin

Function

While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, Sermorelin is used as a diagnostic agent for assessing GH secretory capacity and as a research tool or off-label therapy to increase endogenous GH in GH-deficient or age-related contexts1727.

Mechanism

While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, Sermorelin is a synthetic 29-amino-acid peptide identical to the 1–29 N-terminal fragment of human GHRH that stimulates GH synthesis and secretion by binding pituitary GHRH receptors1727120.

Length and Sequence

Epitalon is 4 amino acids long, whereas Sermorelin is longer as it has a length of 29 amino acids. Epitalon is made up of a sequence of Alanine, Glutamic acid, Aspartic acid, Glycine. Sermorelin is made up of a sequence of Tyrosine, Alanine, Aspartic acid, Alanine, Isoleucine, Phenylalanine, Threonine, Asparagine, Serine, Tyrosine, Arginine, Lysine, Valine, Leucine, Glycine, Glutamine, Leucine, Serine, Alanine, Arginine, Lysine, Leucine, Leucine, Glutamine, Aspartic acid, Isoleucine, Methionine, Serine, Arginine.

Receptor

Epitalon

Binds nuclear histone proteins (H1, H2B, H3, H4) rather than a classic membrane receptor36

Sermorelin

Growth hormone–releasing hormone receptor (GHRHR) on pituitary somatotrophs94103120

Organism or Origin

Epitalon

Synthetic peptide modeled after a pineal gland peptide fraction; not directly encoded as a standalone peptide in humans36

Sermorelin

Synthetic peptide corresponding to human hypothalamic GHRH(1–29) 17120

Gene

Epitalon

Not assigned in the current dataset.

Sermorelin

GHRH

Related articles

No related articles are linked to these peptides yet.

Sources

36AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/
17Sermorelin - Wikipedia, https://en.wikipedia.org/wiki/Sermorelin
27Sermorelin, https://pubchem.ncbi.nlm.nih.gov/compound/Sermorelin
94Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth-hormone-releasing_hormone_receptor
103Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone_receptor
120Growth hormone–releasing hormone - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone%E2%80%93releasing_hormone