Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
Epitalon is 4 amino acids long, whereas Selank is longer as it has a length of 7 amino acids. Epitalon is made up of a sequence of Alanine, Glutamic acid, Aspartic acid, Glycine. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.
Epitalon
Binds nuclear histone proteins (H1, H2B, H3, H4) rather than a classic membrane receptor36
Selank
Not clearly established in the current dataset.
Epitalon
Not assigned in the current dataset.
Selank
Not assigned in the current dataset.
No related articles are linked to these peptides yet.