Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, Melanotan II is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans3545.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, Melanotan II is a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior3545.
Epitalon
Not assigned in the current dataset.
Melanotan II
POMC
Both peptides fall into a similar broad context as Neuropeptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: Epitalon is more often discussed in the realm of Aging and longevity, whereas Melanotan II is more often associated with the realm of Dermatology and aesthetics and Reproductive health. Their biological logic is quite different: Epitalon is a signaling modulator and a gene expression modulator, whereas Melanotan II is a receptor agonist. Both are synthetic in origin and both are still best understood as being approved for Research use only. Epitalon takes the form of a linear peptide, whereas Melanotan II is closer to a cyclic peptide, while Melanotan II incorporates acetylation features that are not part of Epitalon.
No related articles are linked to these peptides yet.