Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Alanine

Ala / A · hydrophobic residue · neutral charge

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Arginine

Arg / R · basic residue · positive charge

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Asparagine

Asn / N · polar residue · neutral charge

Aspartic acid

Asp / D · acidic residue · negative charge

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide record

Melanotan II

Peptide record

Melanotan II

Function

Melanotan II is a Hormone peptide.

This Peptide is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans35 45

Mechanism

Melanotan II is a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior35 45

Melanotan II is a Receptor agonist.

Receptor

Melanocortin receptors MC1R, MC3R, MC4R, and MC5R (non-selective agonist) 35 45

Length

7 amino acids

Organism or Origin

Synthetic analog of POMC-derived melanocortin peptides35 81 90

Gene

POMC

Sequence

AcN-terminus

C-terminusNH2

Ac-Nle-cyclo[D-H-D-F-R-W-K]-NH2 45

Nle, Aspartic acid, Histidine, Phenylalanine, Arginine, Tryptophan, Lysine

7 residuesapprox. 869.98 Dacharge +3 / -1 / net +2acidic 1 • basic 3 • hydrophobic 21 residues without standard metadata

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sequence-derived properties are omitted because one or more residues are not present in the standard amino-acid dataset.

Sources

35What is melanotan II? - Creative Peptides, https://www.creative-peptides.com/resources/what-is-melanotan-ii-peptide.html
45[PDF] melanotan-II peptide structure and molecular formula - Benchchem, https://www.benchchem.com/pdf/melanotan_II_peptide_structure_and_molecular_formula.pdf
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/

Related articles

No related articles are linked to this peptide yet.