Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.
Epitalon is 4 amino acids long, whereas Matrixyl is longer as it has a length of 5 amino acids. Epitalon is made up of a sequence of Alanine, Glutamic acid, Aspartic acid, Glycine. Matrixyl is made up of a sequence of Lysine, Threonine, Threonine, Lysine, Serine.
Epitalon
Binds nuclear histone proteins (H1, H2B, H3, H4) rather than a classic membrane receptor36
Matrixyl
Not clearly established in the current dataset.
Epitalon
Not assigned in the current dataset.
Matrixyl
Not assigned in the current dataset.
No related articles are linked to these peptides yet.