Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, LL-37 acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, LL-37 is a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586.
Epitalon
Not assigned in the current dataset.
LL-37
CAMP
The clearest overlap between Epitalon and LL-37 is that both converge around Signaling modulator. Their typical research and application settings separate fairly clearly: Epitalon is more often discussed in the realm of Aging and longevity, whereas LL-37 is more often associated with the realm of Immunology and inflammation and Gastroenterology. Both appear to work through Signaling modulator, but the functional emphasis still separates, with Epitalon leaning toward Mitochondrial function modulation and Antioxidant activity and LL-37 leaning toward Anti-pathogenic, Immune regulation, and Tissue repair and healing. Epitalon has a more synthetic analog origin, while LL-37 is closer to natural endogenous background with Epitalon approved for Research use only and LL-37 in Preclinical development. Their usual administration context is also different, with Epitalon more often associated with subcutaneous injection and intranasal delivery and LL-37 with topical / transdermal and intravenous infusion.
No related articles are linked to these peptides yet.