Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, KPV is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, KPV is the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684.
Epitalon is 4 amino acids long, whereas KPV is shorter as it has a length of 3 amino acids. Epitalon is made up of a sequence of Alanine, Glutamic acid, Aspartic acid, Glycine. KPV is made up of a sequence of Lysine, Proline, Valine.
Epitalon
Not assigned in the current dataset.
KPV
POMC
No related articles are linked to these peptides yet.