Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, KPV is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, KPV is the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684.
Epitalon
Not assigned in the current dataset.
KPV
POMC
Both peptides fall into a similar broad context as Signal peptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: Epitalon is more often discussed in the realm of Aging and longevity, whereas KPV is more often associated with the realm of Immunology and inflammation, Gastroenterology, and Dermatology and aesthetics. Both appear to work through Signaling modulator and Gene expression modulator, but the functional emphasis still separates, with Epitalon leaning toward Mitochondrial function modulation and Antioxidant activity and KPV leaning toward Anti-inflammatory and Immune regulation. Epitalon has a more synthetic analog origin, while KPV is closer to natural endogenous background with Epitalon approved for Research use only and KPV in Preclinical development. They share some route overlap through subcutaneous injection, while the remaining routes diverge.
No related articles are linked to these peptides yet.