Comparison

Epitalon vs GHRP-2

Function

While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, GHRP-2 is used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics6272.

Mechanism

While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, GHRP-2 is a second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol62723096.

Length and Sequence

Epitalon is 4 amino acids long, whereas GHRP-2 is longer as it has a length of 6 amino acids. Epitalon is made up of a sequence of Alanine, Glutamic acid, Aspartic acid, Glycine. GHRP-2 is made up of a sequence of Alanine, D-2-Nal, Alanine, Tryptophan, Phenylalanine, Lysine.

Receptor

Epitalon

Binds nuclear histone proteins (H1, H2B, H3, H4) rather than a classic membrane receptor36

GHRP-2

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 309596104

Organism or Origin

Epitalon

Synthetic peptide modeled after a pineal gland peptide fraction; not directly encoded as a standalone peptide in humans36

GHRP-2

Synthetic met-enkephalin–derived hexapeptide3072

Gene

Epitalon

Not assigned in the current dataset.

GHRP-2

GHSR

Related articles

No related articles are linked to these peptides yet.

Sources

36AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/
30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
62GHRP-2: Potent Growth Hormone Releasing Peptide Guide, https://www.peptidepedia.org/performance/ghrp-2
72GHRP-2 Technical Data - Molecular Specs - Peptide Initiative, https://peptideinitiative.com/peptides/ghrp-2/technical
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor