Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36, GHRP-2 is used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics6272.
While Epitalon works as a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36, GHRP-2 is a second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol62723096.
Epitalon
Not assigned in the current dataset.
GHRP-2
GHSR
Epitalon and GHRP-2 are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Epitalon is more often discussed in the realm of Aging and longevity, whereas GHRP-2 is more often associated with the realm of Metabolic and endocrine and Musculoskeletal health. Their biological logic is quite different: Epitalon is a signaling modulator and a gene expression modulator, whereas GHRP-2 is a receptor agonist. Epitalon has a more synthetic analog origin, while GHRP-2 is closer to synthetic design background with Epitalon approved for Research use only and GHRP-2 in Clinical phase 1. GHRP-2 incorporates d-amino acid substitution and amidation features that are not part of Epitalon.
No related articles are linked to these peptides yet.