Peptide record

GHRP-2

Mechanism

Second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol.62 72 30 96

Function

Used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics.62 72

Receptor

Ghrelin/growth hormone secretagogue receptor (GHSR-1a). 30 95 96 104

Sequence

D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH262 72

Length

6 amino acids

Organism or Origin

Synthetic met-enkephalin–derived hexapeptide.30 72

Gene

GHSR

Sources

30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
62GHRP-2: Potent Growth Hormone Releasing Peptide Guide, https://www.peptidepedia.org/performance/ghrp-2
72GHRP-2 Technical Data - Molecular Specs - Peptide Initiative, https://peptideinitiative.com/peptides/ghrp-2/technical
95Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren, https://www.nature.com/articles/s41467-021-26735-5
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
104Variations in the Ghrelin Receptor Gene Associate with Obesity and Glucose Metabolism in Individuals with Impaired Glucose Tolerance, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0002941

No related articles are linked to this peptide yet.