Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While CJC-1295 is used in research to chronically elevate endogenous growth hormone and IGF-1 levels, enabling studies of body composition, metabolic, and anti-aging effects of prolonged GH exposure10, Ipamorelin is investigated for producing moderate, physiologic-like GH pulses useful for studying anabolic, body-composition, and recovery effects with a relatively clean endocrine side-effect profile compared with earlier GHRPs16.
While CJC-1295 works as a tetrasubstituted 29-amino-acid analog of GHRH(1–29) that acts as a potent agonist at the GHRH receptor and, in its DAC form, covalently binds serum albumin to extend half-life from minutes to days, resulting in sustained pulsatile GH and IGF-1 increase1082, Ipamorelin is a third-generation pentapeptide growth hormone secretagogue that selectively agonizes the ghrelin (GHSR-1a) receptor to trigger controlled, GH-specific pituitary release with minimal effects on cortisol or prolactin16269596.
CJC-1295
GHRH
Ipamorelin
GHSR
Both peptides fall into a similar broad context as Hormone peptides, although the details of how they are used and discussed still diverge. Both are often discussed in Metabolic and endocrine contexts, while CJC-1295 is more of a hormone peptide and Ipamorelin is better described as a hormone peptide. Both appear to work through Receptor agonist, but the functional emphasis still separates, with CJC-1295 leaning toward Metabolic regulation and Ipamorelin leaning toward Anabolic growth and Lipolysis and fat loss. CJC-1295 has a more synthetic analog origin, while Ipamorelin is closer to synthetic design background and both are still best understood as being in Preclinical development. CJC-1295 takes the form of a peptide conjugate, whereas Ipamorelin is closer to a linear peptide, while their sequence patterns also diverge, with CJC-1295 showing alpha-helical domain features and Ipamorelin showing protein-mimetic sequence features.