Peptable

Peptide record

Ipamorelin

Function

Ipamorelin is a Hormone peptide.

This Peptide is investigated for producing moderate, physiologic-like GH pulses useful for studying anabolic, body-composition, and recovery effects with a relatively clean endocrine side-effect profile compared with earlier GHRPs16

Mechanism

Ipamorelin is a third-generation pentapeptide growth hormone secretagogue that selectively agonizes the ghrelin (GHSR-1a) receptor to trigger controlled, GH-specific pituitary release with minimal effects on cortisol or prolactin16269596

Ipamorelin is a Receptor agonist.

Receptor

Ghrelin/growth hormone secretagogue receptor type 1a (GHSR-1a)169596104

Length

5 amino acids

Organism or Origin

Fully synthetic peptide ghrelin mimetic16

Gene

GHSR

Sequence

N-terminusC-terminusNH2

Aib-H-D-2-Nal-D-F-K-NH2 16

Aib, Histidine, D-2-Nal, Phenylalanine, Lysine

5 residuesapprox. 412.49 Dacharge +2 / -0 / net +2basic 2 • hydrophobic 12 residues without standard metadata

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sequence-derived properties are omitted because one or more residues are not present in the standard amino-acid dataset.

Sources

  1. 16Ipamorelin peptide: A gentle pulse, but is it strong enough?, https://oathpeptides.com/2025/11/05/ipamorelin-peptide-a-gentle-pulse-but-is-it-strong-enough/
  2. 26Ipamorelin Research — Selective GH Secretagogue, Preclinical ..., https://peptide.co/research/ipamorelin/
  3. 95Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren, https://www.nature.com/articles/s41467-021-26735-5
  4. 96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
  5. 104Variations in the Ghrelin Receptor Gene Associate with Obesity and Glucose Metabolism in Individuals with Impaired Glucose Tolerance, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0002941

Related articles

About this page

Published by
Peptable, as a structured reference dataset.
Dataset updated
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Compiled from published literature and reference databases. See the editorial policy.

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