Mechanism
Third-generation pentapeptide growth hormone secretagogue that selectively agonizes the ghrelin (GHSR-1a) receptor to trigger controlled, GH-specific pituitary release with minimal effects on cortisol or prolactin.16269596
Peptide record
Ipamorelin
Function
Investigated for producing moderate, physiologic-like GH pulses useful for studying anabolic, body-composition, and recovery effects with a relatively clean endocrine side-effect profile compared with earlier GHRPs.16
Receptor
Ghrelin/growth hormone secretagogue receptor type 1a (GHSR-1a).169596104
Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH216
Length
5 amino acids
Organism or Origin
Fully synthetic peptide ghrelin mimetic.16
Gene
GHSR
Sources
- 16Ipamorelin peptide: A gentle pulse, but is it strong enough?, https://oathpeptides.com/2025/11/05/ipamorelin-peptide-a-gentle-pulse-but-is-it-strong-enough/
- 26Ipamorelin Research — Selective GH Secretagogue, Preclinical ..., https://peptide.co/research/ipamorelin/
- 95Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren, https://www.nature.com/articles/s41467-021-26735-5
- 96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
- 104Variations in the Ghrelin Receptor Gene Associate with Obesity and Glucose Metabolism in Individuals with Impaired Glucose Tolerance, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0002941