Function
CJC-1295 is a Hormone peptide.
This Peptide is used in research to chronically elevate endogenous growth hormone and IGF-1 levels, enabling studies of body composition, metabolic, and anti-aging effects of prolonged GH exposure10
Peptide record
CJC-1295
Peptide record
CJC-1295
Mechanism
CJC-1295 is a tetrasubstituted 29-amino-acid analog of GHRH(1–29) that acts as a potent agonist at the GHRH receptor and, in its DAC form, covalently binds serum albumin to extend half-life from minutes to days, resulting in sustained pulsatile GH and IGF-1 increase1082
CJC-1295 is a Receptor agonist.
Receptor
Growth hormone–releasing hormone receptor (GHRHR) on anterior pituitary somatotrophs1094103
Length
29 amino acids
Organism or Origin
Gene
GHRH
Sequence
Y-D-A-D-A-I-F-T-Q-S-Y-R-K-V-L-A-Q-L-S-A-R-K-L-L-Q-D-I-L-S-R 82
Tyrosine, Alanine, Aspartic acid, Alanine, Isoleucine, Phenylalanine, Threonine, Glutamine, Serine, Tyrosine, Arginine, Lysine, Valine, Leucine, Alanine, Glutamine, Leucine, Serine, Alanine, Arginine, Lysine, Leucine, Leucine, Glutamine, Aspartic acid, Isoleucine, Leucine, Serine, Arginine
29 residuesapprox. 3350.94 Dacharge +5 / -2 / net +3polar 9 • hydrophobic 13 • acidic 2 • basic 5
Sequence-derived properties
Length
29 residues
Molecular weight
3368.96 Da
Average hydrophobicity
-0.08
Unique amino acids
12
Residue class composition
hydrophobic
13 (44.8%)
polar
9 (31%)
basic
5 (17.2%)
acidic
2 (6.9%)
Charge-category composition
neutral
22 (75.9%)
positive
5 (17.2%)
negative
2 (6.9%)
Amino acid composition
Leucine (Leu/L)
5 (17.2%)
Alanine (Ala/A)
4 (13.8%)
Arginine (Arg/R)
3 (10.3%)
Glutamine (Gln/Q)
3 (10.3%)
Serine (Ser/S)
3 (10.3%)
Aspartic acid (Asp/D)
2 (6.9%)
Isoleucine (Ile/I)
2 (6.9%)
Lysine (Lys/K)
2 (6.9%)
Tyrosine (Tyr/Y)
2 (6.9%)
Phenylalanine (Phe/F)
1 (3.4%)
Threonine (Thr/T)
1 (3.4%)
Valine (Val/V)
1 (3.4%)
Sources
- 10CJC-1295: Long-Acting GHRH Analog - Alpha Carbon Labs, https://alphacarbonlabs.com/blog/cjc-1295-long-acting-ghrh-analog
- 82CJC-1295 no DAC 5mg (Mod GRF 1-29), https://www.peptidesciences.com/mod-grf-1-29-5mg-cjc-1295-no-dac
- 94Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth-hormone-releasing_hormone_receptor
- 103Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone_receptor
- 120Growth hormone–releasing hormone - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone%E2%80%93releasing_hormone