Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

Thymosin Beta-4

Function

Thymosin Beta-4 is a Signal peptide.

This Peptide promotes wound healing, angiogenesis, and tissue regeneration in preclinical models via effects on cytoskeleton dynamics, cell migration, and anti-apoptotic pathways25579

Mechanism

Thymosin Beta-4 is an endogenous 43-amino-acid actin-sequestering peptide that maintains a pool of G-actin monomers and regulates actin polymerization, thereby influencing cell migration, proliferation, and differentiation25579

Thymosin Beta-4 is a Signaling modulator.

Receptor

Binds actin monomers (G-actin) at both barbed and pointed ends to sterically block polymerization55

Length

43 amino acids

Organism or Origin

Human and other mammals (ubiquitous cytosolic peptide) 7988

Gene

TMSB4X

Sequence

AcN-terminus
Ser
Asp
Lys
Pro
Asp
Met
Ala
Glu
Ile
Glu
Lys
Phe
Asp
Lys
Ser
Lys
Lys
Pro
Asp
Met
Ala
Glu
Glu
Lys
Phe
Asp
Lys
Lys
Glu
Lys
Lys
Glu
Glu
Ala
Glu
Asn
Glu
Glu
Lys
Glu
Ser
C-terminus

Ac-SDKPDMAEIEKFDKSKKPDMAEEKFDKKEKKEEAENEEKES 212

Serine, Aspartic acid, Lysine, Proline, Aspartic acid, Methionine, Alanine, Glutamic acid, Isoleucine, Glutamic acid, Lysine, Phenylalanine, Aspartic acid, Lysine, Serine, Lysine, Lysine, Proline, Aspartic acid, Methionine, Alanine, Glutamic acid, Glutamic acid, Lysine, Phenylalanine, Aspartic acid, Lysine, Lysine, Glutamic acid, Lysine, Lysine, Glutamic acid, Glutamic acid, Alanine, Glutamic acid, Asparagine, Glutamic acid, Glutamic acid, Lysine, Glutamic acid, Serine

41 residuesapprox. 4858.36 Dacharge +11 / -16 / net -5polar 4 • acidic 16 • basic 11 • special 2 • hydrophobic 8

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sources

  1. 2TB-500 (Thymosin Beta-4) | Peptide Biologix, https://peptidebiologix.com/tb-500
  2. 12Thymosin Beta-4 vs TB-500 | What to Know in 2024, https://www.peptidesciences.com/peptide-research/thymosin-beta-4-vs-tb-500
  3. 55Thymosin β4 Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed Ends†, https://pubs.acs.org/doi/abs/10.1021/bi970185v
  4. 79TMSB4X Gene: Function, Research, and Clinical Applications, https://learn.mapmygenome.in/genemap/tmsb4x
  5. 88TMSB4X thymosin beta 4, X-linked FX PTMB4 TB4X TMSB4, https://www.sigmaaldrich.com/DE/en/genes/tmsb4x

Related articles

Thymosin Beta-4