Mechanism
Endogenous 43-amino-acid actin-sequestering peptide that maintains a pool of G-actin monomers and regulates actin polymerization, thereby influencing cell migration, proliferation, and differentiation.25579
Peptide record
Thymosin Beta-4
Function
Promotes wound healing, angiogenesis, and tissue regeneration in preclinical models via effects on cytoskeleton dynamics, cell migration, and anti-apoptotic pathways.25579
Receptor
Binds actin monomers (G-actin) at both barbed and pointed ends to sterically block polymerization.55
Sequence
Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Lys-Pro-Asp-Met-Ala-Glu-Glu-Lys-Phe-Asp-Lys-Lys-Glu-Lys-Lys-Glu-Glu-Ala-Glu-Asn-Glu-Glu-Lys-Glu-Ser (Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES)212
Length
43 amino acids
Organism or Origin
Human and other mammals (ubiquitous cytosolic peptide). 7988
Gene
TMSB4X
Sources
- 2TB-500 (Thymosin Beta-4) | Peptide Biologix, https://peptidebiologix.com/tb-500
- 12Thymosin Beta-4 vs TB-500 | What to Know in 2024, https://www.peptidesciences.com/peptide-research/thymosin-beta-4-vs-tb-500
- 55Thymosin β4 Binds Actin in an Extended Conformation and Contacts both the Barbed and Pointed Ends†, https://pubs.acs.org/doi/abs/10.1021/bi970185v
- 79TMSB4X Gene: Function, Research, and Clinical Applications, https://learn.mapmygenome.in/genemap/tmsb4x
- 88TMSB4X thymosin beta 4, X-linked FX PTMB4 TB4X TMSB4, https://www.sigmaaldrich.com/DE/en/genes/tmsb4x