Peptide record

Humanin

Mechanism

Mitochondrial-derived 24-amino-acid peptide that protects cells against diverse apoptotic insults by interacting with cell-surface cytokine receptor complexes and intracellular targets, thereby activating pro-survival STAT3 and other pathways.7 136 141

Function

Exerts neuroprotective and cytoprotective effects in models of Alzheimer’s disease, ischemia, and metabolic stress, reducing apoptosis and improving cell survival.7 136 141

Receptor

Binds a trimeric cytokine receptor complex consisting of CNTFR, WSX-1, and gp130, and can also signal via the G-protein–coupled receptor FPRL1/FPR2.136 141

Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala (MAPRGFSCLLLLTSEIDLPVKRRA)53

Length

24 amino acids

Organism or Origin

Human mitochondrial peptide encoded within the 16S rRNA gene region.76 85

Gene

MT-RNR2

Sources

7Evidence of natural selection in the mitochondrial-derived peptides ..., https://www.nature.com/articles/s41598-023-41053-0
53Frequently Asked Questions, https://www.peptidejournal.org/peptides/humanin-mitochondrial-peptide-research
76Humanin - Wikipedia, https://en.wikipedia.org/wiki/Humanin
85MT-RNR2 - Wikipedia, https://en.wikipedia.org/wiki/MT-RNR2
136Humanin Inhibits Neuronal Cell Death by Interacting with a Cytokine Receptor Complex or Complexes Involving CNTF Receptor α/WSX-1/gp130 | Molecular Biology of the Cell, https://www.molbiolcell.org/doi/full/10.1091/mbc.e09-02-0168
141Humanin: a harbinger of mitochondrial-derived peptides? - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC3641182/

No related articles are linked to this peptide yet.