Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39, Setmelanotide is approved for chronic weight management in patients with POMC, PCSK1, LEPR deficiencies and Bardet–Biedl syndrome by reducing hunger and promoting weight loss92.
While Selank works as a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39, Setmelanotide is a potent synthetic melanocortin-4 receptor (MC4R) agonist derived from a POMC/α-MSH–related sequence that restores downstream MC4R signaling in genetic obesity syndromes3192100.
Selank
Not assigned in the current dataset.
Setmelanotide
POMC
Both peptides fall into a similar broad context as Neuropeptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: Selank is more often discussed in the realm of Neurology and brain health and Immunology and inflammation, whereas Setmelanotide is more often associated with the realm of Metabolic and endocrine. They also influence different molecular systems, with Selank tracking more closely to GPCR receptor while Setmelanotide centers more on Melanocortin receptor. Selank has a more synthetic analog origin, while Setmelanotide is closer to synthetic design background and their development context also differs, with Selank approved for Research use only while Setmelanotide is approved. Selank takes the form of a linear peptide, whereas Setmelanotide is closer to a cyclic peptide, Setmelanotide incorporates d-amino acid substitution features that are not part of Selank; while their sequence patterns also diverge, with Selank showing proline-rich features and Setmelanotide showing protein-mimetic sequence features.
No related articles are linked to these peptides yet.