Comparison

Selank vs Sermorelin

Function

While Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39, Sermorelin is used as a diagnostic agent for assessing GH secretory capacity and as a research tool or off-label therapy to increase endogenous GH in GH-deficient or age-related contexts1727.

Mechanism

While Selank works as a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39, Sermorelin is a synthetic 29-amino-acid peptide identical to the 1–29 N-terminal fragment of human GHRH that stimulates GH synthesis and secretion by binding pituitary GHRH receptors1727120.

Length and Sequence

Selank is 7 amino acids long, whereas Sermorelin is longer as it has a length of 29 amino acids. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline. Sermorelin is made up of a sequence of Tyrosine, Alanine, Aspartic acid, Alanine, Isoleucine, Phenylalanine, Threonine, Asparagine, Serine, Tyrosine, Arginine, Lysine, Valine, Leucine, Glycine, Glutamine, Leucine, Serine, Alanine, Arginine, Lysine, Leucine, Leucine, Glutamine, Aspartic acid, Isoleucine, Methionine, Serine, Arginine.

Receptor

Selank

Not clearly established in the current dataset.

Sermorelin

Growth hormone–releasing hormone receptor (GHRHR) on pituitary somatotrophs94103120

Organism or Origin

Selank

Synthetic analog of the IgG-derived tetrapeptide tuftsin39

Sermorelin

Synthetic peptide corresponding to human hypothalamic GHRH(1–29) 17120

Gene

Selank

Not assigned in the current dataset.

Sermorelin

GHRH

Related articles

No related articles are linked to these peptides yet.

Sources

39Application of thr-lys-pro-arg-pro-gly-pro peptide (selank) for ..., https://patents.google.com/patent/RU2629832C1/en
17Sermorelin - Wikipedia, https://en.wikipedia.org/wiki/Sermorelin
27Sermorelin, https://pubchem.ncbi.nlm.nih.gov/compound/Sermorelin
94Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth-hormone-releasing_hormone_receptor
103Growth-hormone-releasing hormone receptor - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone_releasing_hormone_receptor
120Growth hormone–releasing hormone - Wikipedia, https://en.wikipedia.org/wiki/Growth_hormone%E2%80%93releasing_hormone