Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Retatrutide is an investigational agent that produces very large body-weight reductions in early trials by simultaneously engaging GLP-1R, GIPR, and GCGR to enhance satiety, energy expenditure, and glycemic control2575, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While Retatrutide works as a triple incretin agonist peptide derived from a GIP backbone and engineered to activate GLP-1, GIP, and glucagon receptors, with non-natural residues and fatty-acid conjugation that confer long half-life and balanced multi-receptor signaling256575, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
Retatrutide
Not assigned in the current dataset.
Selank
Not assigned in the current dataset.
Retatrutide and Selank are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Retatrutide is more often discussed in the realm of Metabolic and endocrine, whereas Selank is more often associated with the realm of Neurology and brain health and Immunology and inflammation. They also influence different molecular systems, with Retatrutide tracking more closely to GLP-1 receptor while Selank centers more on GPCR receptor. Both are synthetic in origin with Retatrutide in Clinical phase 3 and Selank approved for Research use only. Retatrutide takes the form of a peptide conjugate, whereas Selank is closer to a linear peptide, Retatrutide incorporates lipidation features that are not part of Selank; while their sequence patterns also diverge, with Retatrutide showing alpha-helical domain features and Selank showing proline-rich features.