Comparison

Retatrutide vs Selank

Function

While Retatrutide is an investigational agent that produces very large body-weight reductions in early trials by simultaneously engaging GLP-1R, GIPR, and GCGR to enhance satiety, energy expenditure, and glycemic control2575, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.

Mechanism

While Retatrutide works as a triple incretin agonist peptide derived from a GIP backbone and engineered to activate GLP-1, GIP, and glucagon receptors, with non-natural residues and fatty-acid conjugation that confer long half-life and balanced multi-receptor signaling256575, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.

Length and Sequence

Retatrutide is 39 amino acids long, whereas Selank is shorter as it has a length of 7 amino acids. Retatrutide is made up of a sequence of sequence data not available in the current dataset. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.

Receptor

Retatrutide

GLP-1 receptor (GLP1R), GIP receptor (GIPR), and glucagon receptor (GCGR) 256575

Selank

Not clearly established in the current dataset.

Organism or Origin

Retatrutide

Synthetic multi-agonist peptide inspired by human incretins and glucagon657580

Selank

Synthetic analog of the IgG-derived tetrapeptide tuftsin39

Gene

Retatrutide

Not assigned in the current dataset.

Selank

Not assigned in the current dataset.

Sources

25What is the mechanism of action of Retatrutide? - Patsnap Synapse, https://synapse.patsnap.com/article/what-is-the-mechanism-of-action-of-retatrutide
65Retatrutide Molecular Structure and Properties | Peptide Protocol Wiki, https://www.peptideprotocolwiki.com/peptides/retatrutide/molecule
75Retatrutide: The Triple Hormone Agonist (GLP-1/GIP/Gluc, https://formblends.com/research/glp-1/retatrutide-triple-agonist-guide
80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/
39Application of thr-lys-pro-arg-pro-gly-pro peptide (selank) for ..., https://patents.google.com/patent/RU2629832C1/en