Peptable

Peptide record

Retatrutide

Function

Retatrutide is a Metabolic peptide.

This Peptide is an investigational agent that produces very large body-weight reductions in early trials by simultaneously engaging GLP-1R, GIPR, and GCGR to enhance satiety, energy expenditure, and glycemic control2575

Mechanism

Retatrutide is a triple incretin agonist peptide derived from a GIP backbone and engineered to activate GLP-1, GIP, and glucagon receptors, with non-natural residues and fatty-acid conjugation that confer long half-life and balanced multi-receptor signaling256575

Retatrutide is a Receptor agonist.

Receptor

GLP-1 receptor (GLP1R), GIP receptor (GIPR), and glucagon receptor (GCGR) 256575

Sequence note

Approximately 39-amino-acid synthetic peptide derived from a GIP scaffold with Aib residues and C20 fatty-diacid conjugation; triple-agonist design 6575

Length

39 amino acids

Organism or Origin

Synthetic multi-agonist peptide inspired by human incretins and glucagon657580

Gene

Not assigned in the current dataset.

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 25What is the mechanism of action of Retatrutide? - Patsnap Synapse, https://synapse.patsnap.com/article/what-is-the-mechanism-of-action-of-retatrutide
  2. 65Retatrutide Molecular Structure and Properties | Peptide Protocol Wiki, https://www.peptideprotocolwiki.com/peptides/retatrutide/molecule
  3. 75Retatrutide: The Triple Hormone Agonist (GLP-1/GIP/Gluc, https://formblends.com/research/glp-1/retatrutide-triple-agonist-guide
  4. 80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/

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