Peptable

Peptide record

Retatrutide

Function

Retatrutide is a Metabolic peptide.

This Peptide is an investigational agent that produces very large body-weight reductions in early trials by simultaneously engaging GLP-1R, GIPR, and GCGR to enhance satiety, energy expenditure, and glycemic control2575

Mechanism

Retatrutide is a triple incretin agonist peptide derived from a GIP backbone and engineered to activate GLP-1, GIP, and glucagon receptors, with non-natural residues and fatty-acid conjugation that confer long half-life and balanced multi-receptor signaling256575

Retatrutide is a Receptor agonist.

Receptor

GLP-1 receptor (GLP1R), GIP receptor (GIPR), and glucagon receptor (GCGR) 256575

Sequence note

Approximately 39-amino-acid synthetic peptide derived from a GIP scaffold with Aib residues and C20 fatty-diacid conjugation; triple-agonist design 6575

Length

39 amino acids

Organism or Origin

Synthetic multi-agonist peptide inspired by human incretins and glucagon657580

Gene

Not assigned in the current dataset.

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 25What is the mechanism of action of Retatrutide? - Patsnap Synapse, https://synapse.patsnap.com/article/what-is-the-mechanism-of-action-of-retatrutide
  2. 65Retatrutide Molecular Structure and Properties | Peptide Protocol Wiki, https://www.peptideprotocolwiki.com/peptides/retatrutide/molecule
  3. 75Retatrutide: The Triple Hormone Agonist (GLP-1/GIP/Gluc, https://formblends.com/research/glp-1/retatrutide-triple-agonist-guide
  4. 80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/

Related articles

About this page

Published by
Peptable, as a structured reference dataset.
Dataset updated
Sourcing
Compiled from published literature and reference databases. See the editorial policy.

This page is reference information, not medical advice, and describes no dosages or administration protocols. Read the full disclaimer.