Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While MOTS-c improves insulin sensitivity, enhances glycolysis, reduces oxidative stress, and shows protective effects in models of metabolic syndrome, aging, and ischemia-reperfusion injury8135146, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While MOTS-c works as a 16-amino-acid mitochondrial-derived peptide that translocates to the nucleus under metabolic stress and regulates glucose and lipid metabolism largely via activation of AMPK and modulation of mTOR and folate-cycle–linked pathways854140146, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
MOTS-c
MT-RNR1
Selank
Not assigned in the current dataset.
MOTS-c and Selank are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: MOTS-c is more often discussed in the realm of Metabolic and endocrine and Aging and longevity, whereas Selank is more often associated with the realm of Neurology and brain health and Immunology and inflammation. They also influence different molecular systems, with MOTS-c tracking more closely to Mitochondrial membrane while Selank centers more on GPCR receptor. MOTS-c has a more mitochondrial-encoded origin, while Selank is closer to synthetic analog background with MOTS-c in Preclinical development and Selank approved for Research use only. Their sequence patterns also diverge, with MOTS-c showing hydrophobic domain features and Selank showing proline-rich features.
No related articles are linked to these peptides yet.