Mechanism
16-amino-acid mitochondrial-derived peptide that translocates to the nucleus under metabolic stress and regulates glucose and lipid metabolism largely via activation of AMPK and modulation of mTOR and folate-cycle–linked pathways.854140146
Peptide record
MOTS-c
Function
Improves insulin sensitivity, enhances glycolysis, reduces oxidative stress, and shows protective effects in models of metabolic syndrome, aging, and ischemia-reperfusion injury.8135146
Receptor
No dedicated cell-surface receptor has been definitively identified; signaling is primarily described via intracellular AMPK and related metabolic pathways.8135146
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)54
Length
16 amino acids
Organism or Origin
Human mitochondrial peptide encoded in the 12S rRNA gene region.54146
Gene
MT-RNR1
Sources
- 8Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet ..., https://www.nature.com/articles/s12276-025-01521-1
- 54MOTS-c - Wikipedia, https://en.wikipedia.org/wiki/MOTS-c
- 135MOTS-c Promotes Glycolysis via AMPK-HIF-1α-PFKFB3 ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/40035775/
- 140MOTS-c interacts synergistically with exercise intervention ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/33722744/
- 146MOTS-c: A promising mitochondrial-derived peptide for therapeutic ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/
Related articles
No related articles are linked to this peptide yet.