Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

MOTS-c

Function

MOTS-c is a Mitochondrial peptide.

This Peptide improves insulin sensitivity, enhances glycolysis, reduces oxidative stress, and shows protective effects in models of metabolic syndrome, aging, and ischemia-reperfusion injury8135146

Mechanism

MOTS-c is a 16-amino-acid mitochondrial-derived peptide that translocates to the nucleus under metabolic stress and regulates glucose and lipid metabolism largely via activation of AMPK and modulation of mTOR and folate-cycle–linked pathways854140146

MOTS-c is a Gene expression modulator.

Receptor

No dedicated cell-surface receptor has been definitively identified; signaling is primarily described via intracellular AMPK and related metabolic pathways8135146

Length

16 amino acids

Organism or Origin

Human mitochondrial peptide encoded in the 12S rRNA gene region54146

Gene

MT-RNR1

Sequence

N-terminus
Met
Arg
Trp
Gln
Glu
Met
Gly
Tyr
Ile
Phe
Tyr
Pro
Arg
Lys
Leu
Arg
C-terminus

MRWQEMGYIFYPRKLR 54

Methionine, Arginine, Tryptophan, Glutamine, Glutamic acid, Methionine, Glycine, Tyrosine, Isoleucine, Phenylalanine, Tyrosine, Proline, Arginine, Lysine, Leucine, Arginine

16 residuesapprox. 2156.61 Dacharge +4 / -1 / net +3hydrophobic 6 • basic 4 • polar 3 • acidic 1 • special 2

Sequence-derived properties

Length

16 residues

Molecular weight

2174.63 Da

Average hydrophobicity

-0.94

Unique amino acids

12

Residue class composition

hydrophobic

6 (37.5%)

basic

4 (25%)

polar

3 (18.8%)

special

2 (12.5%)

acidic

1 (6.3%)

Charge-category composition

neutral

11 (68.8%)

positive

4 (25%)

negative

1 (6.3%)

Amino acid composition

Arginine (Arg/R)

3 (18.8%)

Methionine (Met/M)

2 (12.5%)

Tyrosine (Tyr/Y)

2 (12.5%)

Glutamic acid (Glu/E)

1 (6.3%)

Glutamine (Gln/Q)

1 (6.3%)

Glycine (Gly/G)

1 (6.3%)

Isoleucine (Ile/I)

1 (6.3%)

Leucine (Leu/L)

1 (6.3%)

Lysine (Lys/K)

1 (6.3%)

Phenylalanine (Phe/F)

1 (6.3%)

Proline (Pro/P)

1 (6.3%)

Tryptophan (Trp/W)

1 (6.3%)

Sources

  1. 8Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet ..., https://www.nature.com/articles/s12276-025-01521-1
  2. 54MOTS-c - Wikipedia, https://en.wikipedia.org/wiki/MOTS-c
  3. 135MOTS-c Promotes Glycolysis via AMPK-HIF-1α-PFKFB3 ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/40035775/
  4. 140MOTS-c interacts synergistically with exercise intervention ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/33722744/
  5. 146MOTS-c: A promising mitochondrial-derived peptide for therapeutic ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC9905433/

Related articles

No related articles are linked to this peptide yet.

About this page

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Peptable, as a structured reference dataset.
Dataset updated
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Compiled from published literature and reference databases. See the editorial policy.

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