Function
While Melanotan II is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans3545, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
Mechanism
While Melanotan II works as a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior3545, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
Length and Sequence
Melanotan II is 7 amino acids long, whereas Selank is the same length as it has a length of 7 amino acids. Melanotan II is made up of a sequence of Nle, Aspartic acid, Histidine, Phenylalanine, Arginine, Tryptophan, Lysine. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.