Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Melanotan II is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans3545, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While Melanotan II works as a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior3545, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
Melanotan II
POMC
Selank
Not assigned in the current dataset.
Both peptides fall into a similar broad context as Neuropeptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: Melanotan II is more often discussed in the realm of Dermatology and aesthetics and Reproductive health, whereas Selank is more often associated with the realm of Neurology and brain health and Immunology and inflammation. They also influence different molecular systems, with Melanotan II tracking more closely to Melanocortin receptor while Selank centers more on GPCR receptor. Both are synthetic in origin and both are still best understood as being approved for Research use only. Melanotan II takes the form of a cyclic peptide, whereas Selank is closer to a linear peptide, Melanotan II incorporates acetylation features that are not part of Selank; while their sequence patterns also diverge, with Melanotan II showing protein-mimetic sequence features and Selank showing proline-rich features.
No related articles are linked to these peptides yet.