Comparison

Melanotan II vs Selank

Function

While Melanotan II is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans3545, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.

Mechanism

While Melanotan II works as a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior3545, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.

Length and Sequence

Melanotan II is 7 amino acids long, whereas Selank is the same length as it has a length of 7 amino acids. Melanotan II is made up of a sequence of Nle, Aspartic acid, Histidine, Phenylalanine, Arginine, Tryptophan, Lysine. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.

Receptor

Melanotan II

Melanocortin receptors MC1R, MC3R, MC4R, and MC5R (non-selective agonist) 3545

Selank

Not clearly established in the current dataset.

Organism or Origin

Melanotan II

Synthetic analog of POMC-derived melanocortin peptides358190

Selank

Synthetic analog of the IgG-derived tetrapeptide tuftsin39

Gene

Melanotan II

POMC

Selank

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

35What is melanotan II? - Creative Peptides, https://www.creative-peptides.com/resources/what-is-melanotan-ii-peptide.html
45[PDF] melanotan-II peptide structure and molecular formula - Benchchem, https://www.benchchem.com/pdf/melanotan_II_peptide_structure_and_molecular_formula.pdf
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/
39Application of thr-lys-pro-arg-pro-gly-pro peptide (selank) for ..., https://patents.google.com/patent/RU2629832C1/en