Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Matrixyl is 5 amino acids long, whereas SS-31 is shorter as it has a length of 4 amino acids. Matrixyl is made up of a sequence of Lysine, Threonine, Threonine, Lysine, Serine. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.
Matrixyl
Not assigned in the current dataset.
SS-31
Not assigned in the current dataset.
No related articles are linked to these peptides yet.