Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Matrixyl
Not assigned in the current dataset.
SS-31
Not assigned in the current dataset.
Matrixyl and SS-31 are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Matrixyl is more often discussed in the realm of Dermatology and aesthetics, whereas SS-31 is more often associated with the realm of Aging and longevity and Cardiovascular health. They also influence different molecular systems, with Matrixyl tracking more closely to Extracellular matrix proteins while SS-31 centers more on Mitochondrial membrane. Both are synthetic in origin and their development context also differs, with Matrixyl cosmetic grade while SS-31 is in Clinical phase 2. Matrixyl takes the form of a peptide conjugate, whereas SS-31 is closer to a linear peptide, Matrixyl carries palmitoylation features, while SS-31 instead reflects d-amino acid substitution and amidation changes; while their sequence patterns also diverge, with Matrixyl showing protein-mimetic sequence features and SS-31 showing cationic amphipathic features.
No related articles are linked to these peptides yet.