Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
Matrixyl
Not clearly established in the current dataset.
Selank
Not clearly established in the current dataset.
Matrixyl
Not assigned in the current dataset.
Selank
Not assigned in the current dataset.
Matrixyl and Selank are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Matrixyl is more often discussed in the realm of Dermatology and aesthetics, whereas Selank is more often associated with the realm of Neurology and brain health and Immunology and inflammation. They also influence different molecular systems, with Matrixyl tracking more closely to Extracellular matrix proteins while Selank centers more on GPCR receptor. Matrixyl has a more synthetic design origin, while Selank is closer to synthetic analog background and their development context also differs, with Matrixyl cosmetic grade while Selank is approved for Research use only. Matrixyl takes the form of a peptide conjugate, whereas Selank is closer to a linear peptide, Matrixyl incorporates palmitoylation features that are not part of Selank; while their sequence patterns also diverge, with Matrixyl showing protein-mimetic sequence features and Selank showing proline-rich features.
No related articles are linked to these peptides yet.